Dr. Elke Bogaert
"In 2010 I obtained my PhD in Biomedical sciences by doing research on the neurodegenerative disorder ALS in Leuven. I continued working in this research field as a post-doctoral fellow for 7 more years, performing research, mentoring students and teaching. In 2019, I joinded the research team of professor Dermaut as a senior scientist working on rare familial disease with a focus on neurodegeneration. Both human cellular models as well as small animal models, Drosophila and Zebrafish are cornerstones of our research in the lab."
Publications
Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer's disease.
Denechaud M, Geurs S, Comptdaer T, Bégard S, Garcia-Núñez A, Pechereau LA, Bouillet T, Vermeiren Y, De Deyn PP, Perbet R, Deramecourt V, Maurage CA, Vanderhaegen M, Vanuytven S, Lefebvre B, Bogaert E, Déglon N, Voet T, Colin M, Buée L, Dermaut B*, Galas MC*. *co-last authors
Prog Neurobiol. 2022 Dec 5:102386. doi: 10.1016/j.pneurobio.2022.102386.
PMID: 36481386.
Shortcutting the diagnostic odyssey: the multidisciplinary Program for Undiagnosed Rare Diseases in adults (UD-PrOZA).
Schuermans N, Hemelsoet D, Terryn W, Steyaert S, Van Coster R, Coucke PJ, Steyaert W, Callewaert B, Bogaert E, Verloo P, Vanlander AV, Debackere E, Ghijsels J, LeBlanc P, Verdin H, Naesens L, Haerynck F, Callens S, Dermaut B, Poppe B; for UD-PrOZA.
Orphanet J Rare Dis. 2022 May 23;17(1):210. doi: 10.1186/s13023-022-02365-y.
PMID: 35606766
Expanding the TDP-43 Proteinopathy Pathway From Neurons to Muscle: Physiological and Pathophysiological Functions.
Versluys L, Ervilha Pereira P, Schuermans N, De Paepe B, De Bleecker JL, Bogaert E*, Dermaut B*.
Front Neurosci. 2022 Feb 3;16:815765. doi: 10.3389/fnins.2022.815765. eCollection 2022. PMID: 35185458 *shared last authorship
Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPARγ signaling.
Schuermans N*, El Chehadeh S*,Hemelsoet D*, Bogaert E, Debackere E, Hilbert P, Van Doninck N, Taquet MC, Rosseel T, De Clercq G, Van Haverbeke C, Chanson JB, Funalot B, Authier FJ, Kaya S, Terryn W, Callens S, Depypere B, Van Dorpe J, Program for Undiagnosed Diseases (UD-PrOZA), Poppe B, Depienne C, Dermaut B.
BioRXiv. 2021 April. doi: https://doi.org/10.1101/2021.04.15.439941 - online ahead of print
* contributed equally
FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins.
Steyaert J, Scheveneels W, Vanneste J, Van Damme P, Robberecht W, Callaerts P, Bogaert E, Van Den Bosch L.
Hum Mol Genet. 2018 Dec 1;27(23):4103-4116. doi: 10.1093/hmg/ddy303.
PMID: 30379317
Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.
Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L.
Cell Rep. 2018 Jul 17;24(3):529-537.e4. doi: 10.1016/j.celrep.2018.06.070.
PMID: 30021151
A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism.
Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs AM, Petrucelli L, Lemmens R, Van Damme P, Van Den Bosch L, Robberecht W.
Acta Neuropathol. 2018 Mar;135(3):427-443. doi: 10.1007/s00401-017-1796-5. Epub 2018 Jan 4.
PMID: 29302778
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L.
Mol Cell. 2017 Mar 16;65(6):1044-1055.e5. doi: 10.1016/j.molcel.2017.02.013.
PMID: 28306503
Inside out: the role of nucleocytoplasmic transport in ALS and FTLD.
Boeynaems S, Bogaert E, Van Damme P, Van Den Bosch L.
Acta Neuropathol. 2016 Aug;132(2):159-173. doi: 10.1007/s00401-016-1586-5. Epub 2016 Jun 6.
PMID: 27271576
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.
Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovičić A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L.
Sci Rep. 2016 Feb 12;6:20877. doi: 10.1038/srep20877.
PMID: 26869068
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS.
Jovičić A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW 3rd, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD.
Nat Neurosci. 2015 Sep;18(9):1226-9. doi: 10.1038/nn.4085.
PMID: 26308983
Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice.
Staats KA, Bogaert E, Hersmus N, Jaspers T, Luyten T, Bultynck G, Parys JB, Hisatsune C, Mikoshiba K, Van Damme P, Robberecht W, Van Den Bosch L.
Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):210-3. doi: 10.1016/j.bbrc.2012.10.094. Epub 2012 Nov 3.
PMID: 23131553
HDAC6 at the Intersection of Neuroprotection and Neurodegeneration.
d'Ydewalle C, Bogaert E, Van Den Bosch L.
Traffic. 2012 Jun;13(6):771-9. doi: 10.1111/j.1600-0854.2012.01347.x. Epub 2012 Mar 26.
PMID: 22372633
Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis.
Bogaert E, Goris A, Van Damme P, Geelen V, Lemmens R, van Es MA, van den Berg LH, Sleegers K, Verpoorten N, Timmerman V, De Jonghe P, Van Broeckhoven C, Traynor BJ, Landers JE, Brown RH Jr, Glass JD, Al-Chalabi A, Shaw CE, Birve A, Andersen PM, Slowik A, Tomik B, Melki J, Robberecht W, Van Den Bosch L.
Neurobiol Aging. 2012 Feb;33(2):418-20. doi: 10.1016/j.neurobiolaging.2010.03.007. Epub 2010 Apr 20.
PMID: 20409611
G37R SOD1 mutant alters mitochondrial complex I activity, Ca(2+) uptake and ATP production.
Coussee E, De Smet P, Bogaert E, Elens I, Van Damme P, Willems P, Koopman W, Van Den Bosch L, Callewaert G.
Cell Calcium. 2011 Apr;49(4):217-25. doi: 10.1016/j.ceca.2011.02.004. Epub 2011 Mar 8.
PMID: 21388680
VEGF protects motor neurons against excitotoxicity by upregulation of GluR2.
Bogaert E, Van Damme P, Poesen K, Dhondt J, Hersmus N, Kiraly D, Scheveneels W, Robberecht W, Van Den Bosch L.
Neurobiol Aging. 2010 Dec;31(12):2185-91. doi: 10.1016/j.neurobiolaging.2008.12.007. Epub 2009 Jan 29.
PMID: 19185395
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.
Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S; Wellcome Trust Case-Control Consortium (WTCCC), Compston A.
Eur J Hum Genet. 2009 Oct;17(10):1309-13. doi: 10.1038/ejhg.2009.41. Epub 2009 Mar 18.
PMID: 19293837
Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P.
J Neurosci. 2008 Oct 15;28(42):10451-9. doi: 10.1523/JNEUROSCI.1092-08.2008.
PMID: 1892302
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.
Van Damme P, Van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, Carmeliet P, Van Den Bosch L, Robberecht W.
J Cell Biol. 2008 Apr 7;181(1):37-41. doi: 10.1083/jcb.200712039. Epub 2008 Mar 31.
PMID: 18378771
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.
Van Damme P, Bogaert E, Dewil M, Hersmus N, Kiraly D, Scheveneels W, Bockx I, Braeken D, Verpoorten N, Verhoeven K, Timmerman V, Herijgers P, Callewaert G, Carmeliet P, Van Den Bosch L, Robberecht W.
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14825-30. doi: 10.1073/pnas.0705046104. Epub 2007 Sep 5.
PMID: 17804792
Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases.
Bogaert E, Van Damme P, Van Den Bosch L, Robberecht W.
Muscle Nerve. 2006 Oct;34(4):391-405. doi: 10.1002/mus.20609.
PMID: 16856151